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Year : 2011  |  Volume : 18  |  Issue : 1  |  Page : 22-25

Characterization of human rotavirus subgroups and serotypes in children under five with acute gastroenteritis in a Saudi Hospital

Department of Microbiology, College of Medicine, University of Dammam, Dammam, Saudi Arabia

Correspondence Address:
Obeid E Obeid
Department of Microbiology, College of Medicine, University of Dammam, P.O. Box 2114, Dammam 31451
Saudi Arabia
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Source of Support: The Deanship of Scientfic Research, King Faisal University (grant number 6110), Conflict of Interest: None

DOI: 10.4103/1319-1683.78634

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Objectives: Rotavirus is the most common cause of severe diarrhea in children. Currently, there is no published data on the prevalence of subgroups and serotypes of rotavirus in the Eastern province of Saudi Arabia. The objectives of the present study were to assess the rotavirus infection in children with acute gastroenteritis and to assess the subgroups and serotypes of rotavirus in the Children and Maternity Hospital in Dammam, Eastern Saudi Arabia. Materials and Methods: Children under 5 years of age with gastroenteritis attending the emergency rooms, or hospitalized in the pediatric wards of in the Children and Maternity Hospital in Dammam were included in the study (N=156). Laboratory diagnosis of rotavirus shedding was established using the novel rotavirus STAT-PAK immunochromatographical test. Subgroup and G-serotype of the positive stool specimens were analyzed by the ELISA method. Results and Conclusions: Using the novel immmunochromatographic assay, 37 samples were shown to be positive for rotavirus (23.7%). Subgroup I (serotype 2) was found to constitute 5.4% of the isolates and subgroup II (serotypes 1, 3 and 4) was found to constitute 56.7% of the isolates, whereas 37.8% were non-typeable. A survey of serotypes of rotavirus in the whole region as well as in the whole of Saudi Arabia will provide important information about the subgroups and groups of rotavirus in the community and may help in assessing the success of the rotavirus vaccine in the future.

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Journal of Family and Community Medicine | Published by Wolters Kluwer - Medknow
Online since 05th September, 2010